They work great with my C9 LED Stringers (screw bulbs, not prelamp). They'll probably work fine with a pre-lamp too, but I can't comment on that. I attach them to the trays, and a key feature of LED bulbs is that this clamp holds the light at an oblique angle - meaning the tip of the bulb is tilted slightly down towards the viewer. This is important for LEDs as they are brightest when you are looking directly at (or near) a point.
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