I have Great Danes and a few other rescue breeds. I've been using this for many years. I always keep a set on hand because you never know when a dog will meet a skunk. So used last week, reordered and used again this week - one dog didn't get a message the first time! It acts gently on fur and skin. Doesn't seem to hurt the ears, nose, or other sensitive areas, which is good since they're usually slapped in the face. We had no reaction to our skin when we bathed her (or my husband) - not even twice a week.
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