We have three Holley regulators in use. We found that the E10 fuel pump fouled the regulators if they were allowed to stay in between racing seasons and we had to disassemble and clean them. On cleaning we found the membrane was weak and coming off, so we now replace it every year. Ethanol attacks the diaphragms of some mechanical fuel pumps and we thought Holley regulators would work with alcohol/methanol. But we don't blame Holly. We blame the caustic, shitty gas.