Payoneer is purposed for businesses, professionals, digital marketers, product/service marketplaces and freelancers. You can not use it for money transfer services to send and receive funds between friends, or as a primary way to pay for things using their prepaid debit card, Payoneer is not for that purpose. Payoneer only accepts business transactions and payments.
Payoneer works well for you if you need to receive payment from clients or market places, it is good for small businesses that needs to get paid for goods and services and the international transactions, it is good for online sellers. It is good for anyone that needs to send and receive business payments all around the globe.
It is widely used in about 200 countries with custom invoice to request money from customers and its customer support is effective.
I therefore recommend that Payoneer does what it does well without exemptions, so if the services you require are within the scope of its dealings kindly go for it without second thought.