Let's do it this way - if you are sitting on the couch, connected your computer to the TV and play something that you can't do with a gamepad, but with a keyboard and mouse, that's your choice. You can put it vertically in general, leaning on your leg tucked under you, it's easy to try any other Kama Sutra position with a keyboard. But if you still sit down at the usual table, then the lining under the palms is very lacking, the brush gets tired of the high keys.