I hadn't heard of Centella/CICA until recently, but it's been great for my skin. It's calming, keeps redness at bay, and my skin feels more impervious to the things it usually reacts to.This is a fantastic ampoule. I use it before using serum and moisturizer, and I've had great results. My sensitive skin can break out, itch, burn, etc. When I use Centella/CICA, it just is NORMAL. I still use other products for other issues, but it does get rid of all the issues I have from sensitivity. RecommendSee full review