Saddle sores are caused by friction and germs in a humid environment. DZ is the best cream I have found for preventing saddle sores. It cools, lubricates, disinfects, and soothes. When bicycle touring, I take along DZ and and also hand sanitizer with aloe. When a laundry is not available, or when camping, I disinfect the pad in my shorts and the area around my sit bones with hand sanitizer first to take care of humidity and germs, then I put a dab of DZ at each sit bone area to eliminate friction. Then I'm set for hot-spot free cycling. This cream is expensive, so using hand sanitizer first makes a DZ tube last a lot longer. BTW, hand sanitizer is an excellent underarm deodorant. It kills BO instantly, doesn't clog your pores, and dries sweat.
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