I ordered this and loved the look and the quality, but 50 liters will not last you a week, only a weekend. The 75-liter retrospective has more space, and I tried it out going to Italy in July 2022. 50 l works as an international carry-on - no sweat.Seventy-five liters also worked without arguing if I left it a good bit empty. I then filled up with duty-free on the return flight.Weight becomes an issue, however. You can walk with 50 l = 40 kg easily anywhere. Lugging 75 l = 60 kg between the Chicago terminals makes you sweat.If you envision this duffel as car luggage, use the 75 l.
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