So far this works better than others I've tried. I am a male with carpal tunnel syndrome and have a 7 inch wrist so I bought the sm/md size as shown in the chart. It's a little tight at times and I hope it loosens up over time. Thumbholes seem to be the main factor in whether or not these braces fit properly. This one is a bit tight so next time I would choose a big one. It's daytime so I can't comment on daytime usage. I tried the "Mueller Fitted Wrist Brace Green Line Number 86271" and thought it was a much more comfortable brace but with less support. I was allergic to it. so i had to keep looking it's a good brace to compare to this one if you look at another brace.
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