I've been through a lot of heartache with this board but I finally got it working reliably on the Raspberry Pi 3 B+ model. The Sense HAT incompatibility cost me several hours. This also does not work on the 1 A+ model. In terms of languages, I've had bad results with JavaScript/nodejs, fairly good results with Python3, and best results with C (WiringPi library). Depending on the device you're talking to, speed seems to be an issue.
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