I actually didn't have a version of the Kayano that I didn't like. For Asics and running they are one of my favorites. They are lighter than other Asics. It takes a while for the shoes to break in (if you walk a lot in the first few days you may get a blister or two. It may be better to run a few miles in the first few days. But you may not even get blisters if you walk a lot, depends on the shape of your foot and the type of shoes you buy). Also, you should always buy running shoes half a size larger than your normal size, as your feet swell when you run. But yes! I love Kayanos and almost every style I've bought, including this one, is among my favorite Asics.
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