On a computer with a Ryzen 7 Pro 4750G processor and a GigaByte B550M motherboard, the S2H started up on XPM profile 2 at 4000 MHz. After ating the BIOS to version F12, XMP profile 1 works stably with a frequency of 4133 MHz. The timings are of course too big, but the voltage is 1.38 volts. All my attempts to overclock were no longer successful. The most likely reason is the cheapest motherboard based on the B550 chipset. Most likely on more advanced boards you can squeeze out more.
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