Review on StarTech.com PCI Express RS232 Serial Adapter Card - PCIe RS232 Serial Host Controller Card - PCIe to Serial DB9 - 16950 UART - Low Profile Expansion Card - Compatible with Windows, macOS, Linux (PEX1S953LP) by Jesse Hughes
Works fine in macOS Big Sur
After upgrading macOS to Big Sur, my TripLite USB-to-Serial keyspan stopped working. The Big Sur requires signed drivers, while the Prolific UART chip in Keyspan does not. StarTech uses an FTDI chip and works right out of the box. No need to install any driver, just add a USB to USB-C adapter to plug it in and you're good to go.
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