works great with Ryzen 5 2600x and (2x8GB) 16GB Crucial Balistix Sport LT 2400MHz (SR) Most of the BIOS settings were already where I wanted them to be, the only thing What I needed was to disable the onboard audio and COM port and set the correct boot order for the optical drive and OS disk. One thing I ran into was that one of my SSDs wasn't running at the correct speed because the SATA 3 and 4 ports share the speed of the bottom M2 slot. So if your SSD is not working, just move it to another port and that will solve the problem. All in all a great motherboard for the price.
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