I hooked it up, connected my Pi to an HDMI display and then typed the commands into the terminal as shown on the instructions page that came with it. The Pi restarted and the display worked fine with the touchscreen! No hassle or need to mess around with additional configuration. This is with a Raspberry Pi 3B+ running standard Raspbian. (Early 2019 version) In the box there was a pen, a display and a small instruction page with 5-6 lines of commands to input. Remains set on subsequent reboots, nothing needs to be changed if you continue to use the screen. You can enter a command to switch the output back to HDMI if you want. The screen has a slightly slow refresh rate but is still comfortable to use. I mainly use it as a status screen in my robotics project.
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