I have some old x99 motherboards that have a few u.2 connectors but only one m.2 slot . This allows me to choose cheap 2.5" U.2 drives for servers that are big, fast, and cheap. They usually come in aluminum cases, which dissipate heat better than the tiny m.2 sticks. In any case, you can do it with this cable. a simple cable, but you also need SATA power.