Use as a base layer under face cream before bed. Retinoids are very sensitive to light, which causes them to break down. While you can wear it during the day, the best time is just before you turn off the lights at night. How much per application is 2 to 3 drops. Using a dropper, place the drops in the palm of your hand and gently massage onto your face. Dry skin may require more product and so too if you are treating your neck. Apply a second dose twice a day in the morning. Even though trans-retinoic acid is affected by light, you'll still benefit from moisturizing omega-3 and 6 fatty acids and antioxidants like p-coumaric acid. Apply sunscreen after morning use. Because retinoids make your skin more susceptible to UV radiation, it's even more important to protect your skin from the sun. It also helps slow down the breakdown of underlying retinoic acid. It has a short shelf life - up to a maximum of 6 months after opening the bottle. This assumes you always keep it tightly closed when not in use and away from heat and light.
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