When I saw the clownish design of the Ultraboost 21 I decided on them. They are as expected very comfortable and fit as expected. Maybe just a little tight, but that's probably because I wear 19s and 20s. Both are likely to be a bit more comfortable in the upper, better fitted to your foot, and better adapted to actual mileage. But the 4.0 is still very comfortable with that classic Boost sole. And I think it's more of a lifestyle shoe. I don't regret the purchase one bit. Not a fan of the 5.0 design (adidas again, less is more). I just wish I hadn't been a few years late to get them so there were more color options.
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