We've been using upguard for several years now in our organization and have not had any issues with it at all! It is easy enough that even someone who has never used an anti-malware tool before can figure out how to set everything up correctly without needing assistance from IT or anyone else within your orgnaization.
Our clients are very happy about this because they don't need help setting things up anymore either - which saves them time too!! Honestly? Nothing so far but we do plan on trying some of these new features soon (like threat hunting) since there aren't many options available as yet if you're looking outside of cloud providers. Security needs/wants - especially when dealing wih sensitive info such as financials, PII etc..