At the end of last year I took Levakhin for suspected SARS. Within a month I developed 29 different symptoms ranging from tendon tears to nervous system issues (brain fog, etc.). I've tried just about everything you can think of - And now I'm going to load myself up with this for a Glutathione trial (1 tablet every hour for 16 hours) - Please see below for the rationale (and why you probably aren't enough get it) One thing about SA-glutathione appears to be a much more bioavailable form of glutathione, significantly more than liposome-based glutathione (Anderson et al., 1985; 2004) - Possesses antiviral activity (Vogel et al., 2005). However, all glutathiones share a common disadvantage; The half-life of glutathione in serum is 10 minutes. According to Hong et al. (2005, Table 1). Glutathione was administered to 7 volunteers as an intravenous injection (50 mg glutathione per kg body weight). Maximum serum levels were reached after 10 minutes. , 10 minutes later. Serum GSH (glutathione) levels returned to control values after 30 minutes. Total GSH decreased from 14.0 to 1219.8 and then returned to baseline after 2 hours. According to Vogel et al. (2005, p. 57) Serum levels of S-acetyl-L-glutathione (S-GSH) and basic glutathione (GSH) increased 8- and 4-fold with S-acetyl-L-glutathione supplementation, respectively. Total GSH levels have been elevated for some time as cellular systems have taken it up directly. Lu (1999) describes treatment with any form of glutathione, which due to the disadvantages I mentioned should be used in /high/ dosages (1000mg?+) to achieve therapeutic levels. This finally explains to me why most glutathione therapies people have tried don't work; You just don't take enough! At first glance, I wonder what happens if I take a pill every hour "during the day". 16 200mg tablets would be enough to sustain elevated serum GSH levels for a long time, possibly to help reverse a mitochondrial dysfunction I was likely having from Levakhine. Citations: Hong, Sae-Yong et al., "Pharmacokinetics of Glutathione and Its Metabolites in Normal Subjects." Journal of Korean Medical Science 20.5 (2005): 721โ726. PMC. Network. August 11, 2016 Anderson, Maine; Giessen, F.; Puri, RN; Meister, A. Glutathione monoethyl ester: tissue uptake and conversion to glutathione. Arc Biochem. biophys. 1985, 239, 538-548. Anderson, Maine; Nilsson, M.; Sims, NR Glutathione monoethyl ester prevents mitochondrial glutathione degradation during focal cerebral ischemia. neurochem. International 2004, 44, 153-159. Molecules 2010, 15.1260 Vogel JU, Cinatl J, Dauletbaev N, Buxbaum S, Treusch G, Cinatl J Jr, Gerein V, Doerr HW. Effects of S-acetylglutathione on a cell and animal model of herpes simplex virus type 1 infection. Honey Microbiol Immunol. January 2005; 194(1-2): 55-9. Epub 2003, November 18. PubMed PMID: 14624358. Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J. 1999 July; 13(10): 1169-83. Review. PubMed PMID: 10385608.
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