I have had this product for a month now and I can confidently say that it is a reliable and affordable option for your 2DS or o3DS system. Lots of storage space, very cheap price (compared to slightly more expensive microSD cards for N3DS systems) and there are no compatibility problems. I bought a 32GB model for reference. I believe higher values require formatting, at least for SD cards if not microSD cards. I still recommend formatting if you get it. I do this thoroughly with all my new storage media (SD, MicroSD, USB stick, hard drive, etc.). that don't have C-Nub, four shoulder buttons, extra processing power, or head-tracking 3D like the new 3DS models. (The new 2DS XL must use microSD cards, so this product shouldn't be bought for it either.)
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