I definitely felt an initial effect when taking this supplement. Not quite the tingling that others have mentioned, but somewhere between a caffeine buzz and a niacin flush. It felt good but after about an hour it quickly turned into a raging headache that lasted for 4 hours. I wondered if it could be a coincidence so I tried again the next day. The same thing. To break, and tried again a few days later. Equally bad. I can believe that this effect wears off over time as the person develops tolerance, but I don't think I have the courage to try. I should also note that I haven't noticed any improvement in athletic performance. These pills end up in the trash.
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