if you are worried about reviews saying it clogs and won't fit the valve stem, don't worry the balls aren't much bigger than coarse sand. I poured them slowly and they flowed surprisingly smoothly. Just a few suggestions. Make sure your bead is seated, you don't want the slack beads under the tire bead. Also, set the wheel in a stable position before connecting the hose and bottle. You should go in little by little, and if you move the wheel it may come loose and you may lose a few beads. If you need to move the wheel midway through, I suggest removing the tube and stabilizing the wheel. Once they are all in I tap on the valve stem to remove all the balls and carefully install the valve core. I haven't read the instructions, but it might be a good idea (laughs) as long as I've replaced the rear tire and put balance balls in it. It couldn't be simpler and runs smoothly at high speeds. To answer the question at what speed they start to work. If we weren't going over 40mph, we wouldn't need to balance our tires. They will work when we need them.
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