I have arthritis in my wrists which is getting worse and a colleague highly recommends this brand. I tried the VM4 during a work day and found it more comfortable but wanted a wireless version. I first bought a medium size but found them a bit small and as they are so expensive I decided not to settle for them and ordered a large. For me it made a huge difference in overall comfort and I'm glad I did. For a mouse this expensive, one would expect a better sensor (it almost needs a mouse pad) and a more rubberized grip. The glossy plastic on this mouse isn't great when you're sweaty, and that's really my biggest gripe. If you need a mouse like this, price probably doesn't matter. It does its job of reducing (but not completely eliminating) wrist stress. It took me a few weeks to get used to the mouse and achieve almost the same accuracy I get with the traditional design. At first you will be disappointed, but it will get better with time.
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