This board was installed in the second PCIe 3.0 x16 slot with a Corsair Force Series MP600 1TB Gen4 PCIe X4 NVMe M.2 SSD. I am using this on a Sabertooth X79 motherboard which is 5 years old at the moment. I was a bit worried as this was the first NVMe SSD I've used outside of a laptop and the fact that my motherboard isn't newer. To my excitement, the drive was recognized at startup. I'm running at Gen 3 speeds but will be upgrading my CPU and motherboard next year when my motherboard has a Gen 4 slot. The SDD is short. I still managed to use it. If you're using NVMe without a heatsink, screw length shouldn't be an issue. Worst case, you can order a longer screw to use with the board.
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