
Agmatine is a very useful supplement with a wide range of uses. One of the most important is that it reduces sensitivity to opioids. As a chronic pain patient, I try to balance the need for relief with the risk of opiate use. Agmatine reduces the dose of opioids required to achieve a given level of pain relief. Agmatine causes a slight decrease in blood pressure and heart rate through the same mechanism of action (alpha-2 agonism) as many heart drugs. Since these drugs are also used to treat anxiety and ADHD, two issues I have, agmatine is also helpful in reducing these symptoms. Agmatine lowers blood sugar levels, improves kidney function, and protects the kidneys from damage.

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