I've had trouble with my Ultra Torins and Merrell Mix Master II on long runs. Especially my Ultra Torins when I had issues with blisters between my toes and just the tip of my metatarsus behind my big toe plus pain right in front of my ankle from the tongue of the shoe. Switched to Zealot Iso a month before the marathon. Thank goodness I ran my first marathon without blisters right at the start of the OC Marathon, even in heavy rain and with wet feet.