These pads work great with 2 guinea pigs. I put bedding shavings on the sheets, and cleaning stains before bed can help you for a few days. Depending on the amount of urine or feces, this can be every day if necessary. I change the pads every 2-3 days, clean the areas they have chosen for their business and put fresh bedding back in. It's important to note that once your fluffy potato has chosen a spot in the bathroom, you can reuse uncontaminated litter with fresh litter after cleaning. Guinea pigs remember familiar places by smell, mix well with fresh and uncolored bedding. We adopted our two piglets from a guinea pig shelter and the owner gave us this recommendation. Keep in mind that not all are created equal, so you may need to clean more often.
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