I wear size 10 1/2 men's shoes with no problems. I ordered them as an 11 as I have wide feet. While the shoe itself does not appear to have a sizing label, the box label read a large number 43. Based on my cycling shoe size, it must have been a size 45. My thumb is 1/4 of what it crushed on the end of the toe box. They were needed this weekend so there's no time to send them back. They are so tight my legs go numb after 15 minutes of wearing them. I only need them for a short trip, then I'll return them. Can't recommend these.
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