My review is not based upon extensive use of this brace - solely upon wearing it around the house for a few hours to determine if the size was acceptable. My thigh measurement was 16" (perhaps 16.5"), clearly within the range of "Medium" size, though at the higher end. Based upon wearing in the house and walking around (not exercising) my lower leg started to feel numb. Clearly I need the Large size. Some have suggested buying two sizes and returning the one that doesn't fit. The other observation is that the velcro gives incredibly strong connection. It is actually kind of hard to take off. Before putting it on I had to unwrap the straps and while doing that it almost felt like I was going to rip off the velcro that was "power-connected" to the brace.All that said, if it fit well, I think that this would have been a pretty good brace for exercising, running, and walking.
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