I have 20-21 inch calves and they fit great. They're long too, which is good, so I don't have to worry, and they cut off in an odd spot on my calf, just like the others. The ONLY complaint I have is that the upper is a little too tight but not uncomfortable. I've worn them all day to the local pride with no problems. My feet felt great, but the upper got a little uncomfortable towards the end. So 8 hours of running was normal. I would be reluctant to recommend much more than that if you have large calves like mine.
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