My hand does not grow fatigued, and even though there are a lot of buttons, I use every single one of them. It is possible to assign almost any commands to the buttons of various applications, which is a really helpful feature. Because I don't put much stock in the horizontal scroll wheel, I make heavy use of the shift key. Another drawback, although I could be doing something wrong here: the computer does not recognize the mouse until either mac OS or Windows has started up. Even when connected to a USB receiver.
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