The gloves are the best and fastest option I've found for keeping my PICC line dry. I wrap my arm first with Glad Press N' Seal (no taping, bend elbow while wrapping) as a precaution. When I tighten the strap, I bend my arm and leave a little extra space in the fingertips to keep my fingers from pressing on the fragile glove fingertips. Also, my gloved hand only holds soap, etc. and washes parts that can't be reached with the ungloved hand. Hair washing is also one-handed. My first one lasted 6 day and wasn't leaking but had lost it's freshness.
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