It is important to understand that 5htp affects the production of serotonin. If you take it with something else that affects serotonin - prescriptions, certain supplements, etc. - you are at risk of developing serotonin syndrome. One of the reviews here describes the symptoms of it - rough sensations, indigestion and general malaise which really scared me to think I was going to die. Normally, I produce less serotonin than usual. Unfortunately, this spoils the effectiveness of antidepressants. Because they limit reuptake, I'm running out of serotonin to support their work. What it's like: I'm fine at first, but after a few months I'll be HUGE. After that, if I increase the dose, it gets worse and I get serotonin syndrome. So originally I was looking for 5htp to increase serotonin production so my antidepressants would be more effective. I was aware of the above side effects and proceeded with caution. Now all I need is a minimal dose of an antidepressant and it works. I have no more crashes and this is the first time in my life that an antidepressant has done and continues to do its job. I've been on the minimum dose of the same antidepressant for a year. Yes, it works that well! And I only need 50mg of 5htp to stay stable.
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