I have a Syba SD-PEX50055 for my MacPro5.1. I put it in the top slot (one of the x4 slots), plugged in the SSDs and booted it up. To my surprise, my Mac booted directly from the SSD on the card and only used the OS drivers. This card is an all-in-one AHCI 1.2 controller with dual 6Gb SATA links. It also gives me two USB 3 slots that also work with internal drivers and negotiate speeds of up to 5Gbps. I'm running this on 10.12.6 with a Samsung Evo 840. On internal SATA I've seen top speeds of around 220MB/s, I'm currently at around 370MB/s. Don't forget to re-enable TRIM or your SSD's performance will slowly drop to horrendously low performance.
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