I installed it in a new cheap ASUS system with Windoze 7 Home Premium (or something like that) and it worked great right out of the box. I didn't have to install any drivers or anything like that. My only minor complaint would be that in the past you could often just plug in a serial cable and it was tight enough that it stayed good enough on its own without the screws getting screwed in. In this case the cable from the device (which I remember being quite tight on the old system) was NOT tight AT ALL, and of course the cable doesn't have any screws so I had to find a few screws or else it would get stuck at the simply moving the cable, not to mention putting the box back on the table.
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