When I was assembling my first PC a few months ago, I bought an NH-D15 without knowing that it was blocking the first PCIe slot on my motherboard. Little did I know at the time that Noctua had a website showing which motherboards would block the first PCIe slot, which was my mistake (don't repeat my mistake, make sure the HSF you want isn't too big for your specific motherboard before you buy it). I got an NH-U12S instead, which worked fine, but I wasn't able to overclock the CPU as much as I wanted. A few months later, Noctua announced the NH-D15S, which was just what I needed. The NH-D15 touched the back of my first GPU, but the NH-D15S has a good inch of clearance from the fan edge and back. For reference, I'm using this with an Intel 5820K. With the NH-U12S, I was able to get up to 4.2GHz at 1.2V while maintaining temperatures below 85°C under full load (Intel XTU stress test). After upgrading to the NH-D15S I'm currently stable at 4.5GHz at 1.275V below 80C (haven't tried to go beyond that yet). The upgrade was worth it and my dream computer just got a little bit better :)
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