I think these are going to be a great multipurpose base layer for me. I've used them for running, when I need a bit of extra insulation. They only provide moderate compression, but that will obviously vary based on your body shape (they're pretty flexible, so I'd advise sizing down if you want good compression). But I had no problem wearing them over calf compression sleeves; they're very smooth, so they slid over them easily; the same would likely be true of a knee brace or other support garments you may need. They are comfortable and quite thin.
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