I've used it on a pair of r9 290s with a modified bios for a better fan profile. Both cards stayed at 68 degrees for about 2 days before the fans started running at higher speeds. In the end, both cards were running at 86+ degrees with 100% fan speed. Upon inspection, I noticed the thermal paste "leaking" out of the GPU die. I reapplied the paste and after a few days I had the same results. I ended up taking a chance with Kpx on one card and Syy 157 on the other. So far, so good.
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