I purchased this product elsewhere to use with Alienware Area-51 R2. Yes and no. First the computer froze when the login screen appeared. I did a google search on this issue and found that the Alienware Command Center is not compatible with 64GB RAM which results in the crash. The workaround is to stop the service named MSICPU_CC. I highly recommend doing this step before installing the memory. Otherwise this is a great product and my Area-51 is now lightning fast!
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