I switched to Injinji socks after getting fed up with blisters from running long distances in regular athletic socks. I have an issue with a second toe that always became a hot spot and blistered after long or strenuous runs no matter what shoe I wore, so I resorted to a sock with minimal success. Even then, from time to time I would get such a bad blister that the nail would die and fall off. Since I switched to these socks, there are no more blisters and lost toenails. I've run 2-3 half marathons, a full marathon, and a few mud runs in Injinji socks with no issues. They are the best. The tongue on the back keeps them from being sucked into the shoe over time, but the overall profile is low enough that you don't get crazy tan lines (and I run in the sun every day and have a complexion that even breaks through 100 SPF sunscreen is used for tanning). ).
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