I use 2 of these for my 24 gallon nanocube. This is in addition to a pouch of Purigen and a pouch of Fosgard. I change everything every 2 months. I have 2 clowns and 3 cardinals. I do 20% water changes weekly and flush them out with every water change. I didn't have any injured or sick fish. My water parameters are always good, super clean and odorless. There is no need to buy packs as this size comes in packs and zips.
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