Preordered this board and finally got it. I have a 3900x, 32GB RAM, Nvidia 2060 RTX in a TU150 case. Everything fit perfectly. Don't worry about the DTX form factor as it fits most ITX cases. I tested the concept on a small Master Elite 110 cooler and it fits great and the case is small. If your AIO case is limited to 120mm, keep an eye on the height of the CPU water block for clearance issues as the fan can be tight against the heatsink. Even if you use 1 fan inside or outside, it still can collide with the CPU. Since most of the blocks are pumps, many of the new ones contain fairly tall RGB lights.
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