Ender 3 has an 8-bit board and the bootloader entry takes up memory that you can use to enable features you might want to use. With USBasp, you can plug it into your board and write firmware directly onto it, saving valuable space. If you're the kind of person who likes to experiment with features and try different firmwares, then this isn't for you. You need to connect it to your printer and computer every time you want to download new firmware. However, if you don't change your firmware, this is a set-and-forget solution and cheaper than the Arduino Uno. It is important to note that the Mac programmer does not require you to install a USB port. Your Mac should initially recognize the device. You CANNOT use the upload button on the Arduino, it cannot be uploaded. You need to go to the menu and select "Download with programmer". When placing the adapter board on top of the I/O pins on the Ender 3 board, you will need to rotate it so that it faces it so that the hole for the included ribbon cable faces the board. and from the front edge of the board. This will align the contacts correctly. Finally, the printer must be switched on.
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