Early research shows that vitamin D is inversely related to melatonin, your sleep hormone.[6] This means that increasing vitamin D levels can lower melatonin levels.[7] So it makes sense that taking it at night might disrupt your sleep. To prevent vitamin D deficiency (particularly during COVID), it is important to monitor vitamin D production and one method is to track personal vitamin D intake in the sun. Therefore, people produce vitamin D in the sun during the day (at least 20 minutes per day) while it decreases at night, allowing for the nocturnal production of melatonin. The production and release of melatonin in the brain depends on the time of day, increasing when it is dark and decreasing when it is light. Flu/cold prophylaxis. Like fmr Peds ER RN I take ZMA whenever I have a 3 night sore throat, runny nose and/or cough and I've never had a flu or cold like Peds ER RN x 10 yr old, real buzz when my wife (health workers too) started to feel bad. I suggested ZMA (women take 66% or 2 caps) for 3 nights, sex improved, no flu or cold days. Flu and cold season, especially during COVID, I always keep a bottle by my bed. Proposal to remove vitD from the Z-Matrix (call it ZZZMA) during COVID and add vitD to the morning supplement (call it AMZ) with NAC, C-ester, CoQ10 and other immune-supporting ingredients as the perfect flu-fighter.
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