First of all I am using this card with my MacBook Pro (Late 2008) with El Capitan 10.11.2. ***THIS IS NOT INTENDED OR RECOMMENDED FOR THIS ***But with a few careful steps and some research, you can do it too. I haven't tried this on any of my Windows machines as they don't have Expresscard slots. This card uses the Renesas uPD720200 chipset (at least mine). This card has been found to work on multiple forums with multiple versions of OSX, but the basics are as follows (on El Capitan): 1. Disable System Integrity Protection (SIP), it cannot be re-enabled if you wish work.2. Get the kext utility (not required but nice and helps with permissions) 3. Get a modified version of AppleUSBXHCI.kext (I used 10.10.5 as a reference). Therefore SIP must be deactivated.4. Make a backup copy of your existing copy of AppleUSBXHCI.kext. You can either do it manually or let the utility do it for you.5. Install Kext using the utility or manually (depending on your preference)6. Restart your Mac and install the map, done. As a side note, if you're running something, you won't be able to get full USB 3.0 speeds on a late 2008 Macbook Pro. HOWEVER you get a noticeable improvement over 2.0 (if you're on a 3.0 device, obviously), overall I was able to reduce my file copy speed by 33%, which is pretty important to me.
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