This is a blockchain-based game, so you need a portfolio to fund your gaming account. CryptoKitties uses MetaMask, one of the most popular portfolios on the market. You can download MetaMask as a Chrome add-on and link your wallet directly to your gaming account. Pretty simple, so you don't have to be a crypto expert to play this game.
Again, I think you need to have crypto experience to play this game. If you know nothing about blockchain or cryptocurrencies, it will be difficult to understand how everything works in this game.
All in all, CryptoKitties can be a fun (but expensive) hobby, but I wonder if anyone will enjoy playing this game for long.